The artificial sweetener erythritol and cardiovascular event risk

Written By Executive Chef Giuseppe Urbano

M Witkowski, I Nemet, H Alamri, J Wilcox, N Gupta, N Nimer, A Haghikia, XS Li, Y Wu, PP Saha, I Demuth, M König, E Steinhagen-Thiessen, T Cajka, O Fiehn, U Landmesser, WHW Tang, SL Hazen

Published: 27 February 2023

This study is an aggregate of several different clinical studies on the association between erythritol, a zero-calorie sweetener, and cardiovascular risk and included prospective and retrospective cohort studies and experiments assessing plasma levels of erythritol after consumption as well as the effects of erythritol on platelet aggregation. The studies showed an association of erythritol blood levels with MACE, with a hazard ratio as high as 4.48 for those in the highest quartile of erythritol levels in one of the Europe-based studies. This risk remained significant when controlled for pre-existing coronary artery disease. The other reported studies suggest a prothrombotic effect of erythritol on platelets in vitro and that post-consumption plasma erythritol levels are above the threshold when these effects are induced in healthy volunteers, suggesting a possible mechanism of action. Read more

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Executive Chef Giuseppe Urbano

Executive Chef Giuseppe Urbano is a Certified Executive Chef, clinical culinary innovator, and the founder of Meals For Longevity™ (MFL). Operating out of the Sarasota, Florida area, Chef Giuseppe has dedicated his career to bridging the gap between gourmet culinary arts and evidence-based clinical nutrition.

He is the architect of the MFL Program Framework™ and the proprietary Dual-Track Nutritional System, which allows clients to seamlessly navigate between the authentic Modern Mediterranean Path and a high-protein New American 2025 (DGA) Upgrade, known as The Metabolic Switch™.

Chef Giuseppe’s protocols are meticulously engineered to combat cardio-metabolic diseases sustainably. His culinary frameworks are strictly aligned with the highest global nutritional standards, including the MedDiet 4.0 updates, LARN 2014/2024 guidelines, and the 2025 Dietary Guidelines for Americans. Through his 28-Day Transformation program and clinical recipe development, he empowers individuals to achieve sustainable weight management, cellular health, and long-term metabolic vitality without sacrificing the joy of eating.

https://www.chefgiuseppeurbano.com
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